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Sodium bisulfite has been used externally for parasitic skin diseases and as gastrointestinal antiseptic. Sodium hydrogensulfite is an inorganic sodium salt having hydrogensulfite as the counterion. It has a role as a mutagen and an allergen. It is an inorganic sodium salt and a sulfite salt.
Sodium bisulfite (NaHSO3) has been used as a reagent to compose the immunoprecipitation (IP) buffer to chemically modify DNA and to synthesize arsenolipids (AsL). It can also be used as a reagent during the synthesis of 5,6-dihydrouracil-6-sulfonate.
In this work we report the successful use of sodium bisulfite as catalyst for the synthesis of 19 benzothiazoles (BZTs) under microwave irradiation with yields from 80% to 100%. BZT-15 was the most active jack bean urease inhibitor exhibiting a mechanism of action typically of a mixed inhibitor. Its affinity to bind urease active site is 3-fold higher than that to bind allosteric site(s). The BZTs 2, 8–10, 15 and 16 are described for the first time as soil ureases inhibitors.