Dimethyl sulfoxide (DMSO) is a small molecule with polar, aprotic and amphiphilic alterations especially in proteins and nucleic acids.
A single dose of DMSO < or =0.1% (2.96 x 10(-5) microM) may be safely used to dilute compounds injected into the vitreous of a rat eye.
The methyl groups of DMSO are only weakly acidic, with a pKa = 35. For this reason, the basicities of many weakly basic organic compounds have been examined.