Product Code ::RXSOL-60-6604-568
Categories: Lab Chemical-60
Product Short Description: ETHYL OLEATE FOR SYNTHESIS 98%
Product Description:

Ethyl oleate uses Ethyl oleate is used as a solvent for pharmaceutical drug preparations involving lipophilic substances such as steroids. It also finds use as a lubricant and a plasticizer.

Product Application:
  1. E 1625 (OTTO) Ethyl oleate, 99% Cas 111-62-6 - used to prepare the oily phase of self-microemulsifying drug delivery system (SMEDDS) for tacrolimus (Tac).
Product Dose:
Product Note:
  1. The ethyl oleate used by the submitters was prepared by esterification of commercial U.S.P. grade oleic acid and fractionated through a Widmer column. The fraction boiling at 160–170°/1 mm., nD25 1.4482–1.4570, iodine value 83.6 (calculated 81.8), was used.
  2. The purity of the absolute ethanol is of prime importance. Ethanol dried only by a lime process gives a low yield (20–25%). The ethanol used in this procedure was dried over lime and then over aluminum tert-butoxide, after which it was distilled directly into the flask used for the reaction.
  3. The submitters used a modified Widmer column; the checkers, a Claisen flask modified with a short Vigreux column.
  4.  
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